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Mature models Skokie

Several psychiatric and neurological diseases are associated with altered hippocampal neurogenesis, suggesting differing neural stem cell NSC function may play a critical role in these diseases. To address this, we established heterogeneous cultures of NSCs isolated from the hippocampal neuropoietic niche. The increased production of immature neurons which fail to mature indicates that this reductionist model retains key animal- and iDG-specific maturational deficits observed in animal models and human patients. This is doubly ificant, as these stem cells lack several developmental inputs present in vivo.

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We tested the hypothesis that an immature dentate gyrus iDGwhose association with psychosis in patients has recently been reported, represents a common phenotype of both diseases. In vitro electrophysiology of dentate gyrus granule cells DG GCs was examined in pilocarpine-treated epileptic mice. : The two disease models demonstrated similar behavioral deficits, such as hyperactivity, Free dating sites North Richland Hills no subscription working memory performance, and social withdrawal. ificant reductions in mRNA expression and immunoreactivity of the mature neuronal marker calbindin and concomitant increases in mRNA expression and immunoreactivity of the immature neuronal marker calretinin represent iDG atures that are present in both mice models.

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